SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SUBSTITUTED DIARYLUREA DERIVATIVES OF BIOLOGICAL INTEREST

Abstract

This research focuses on the synthesis of substituted diarylurea derivatives from aromatic amines and urea nitrate under catalyst-free conditions. The experimental results demonstrate that the nature and position of aromatic substituents influence the efficiency of product formation. FTIR and NMR spectroscopy were used to confirm the structures of the synthesized compounds. The biological interest of diarylureas has been demonstrated in medicinal chemistry, particularly in studies of anticancer and other pharmacologically relevant compounds, while structure–activity relationship studies indicate that modification of the aromatic substituents can substantially influence their biological properties [2]. Therefore, the synthesis and structural characterization of new substituted diarylureas are important for further chemical and biological investigation.

References

1. Arun K. Ghosh, Margherita Brindisi. (2019). Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry.Journal of Medicinal Chemistry.[Crossref]
2. Xueyan Sun, Zhizhong Xie, Xiaoyong Lei, Sheng Huang, Guotao Tang, Zhe Wang. (2023). Research and development of <i>N</i> , <i>N</i> ′-diarylureas as anti-tumor agents.RSC Medicinal Chemistry.[Crossref]
3. (2024). BIFUNCTIONAL-SUBSTITUTED PHTHALOCYANINES.ChemChemTech.[Crossref]

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