MODERN METHODS OF OPTIMIZING THE ETHNOMEDICINE OF CORIANDER SEED (Coriandrum sativum L.)
Abstract
The aim of the study is to analyze the biologically active compounds contained in coriander seed from an ethnomedical perspective and to draw scientifically grounded conclusions by optimizing modern analytical methods (ATR-FTIR, GC-MS) for their identification. Optimization combined classical extraction with modern instrumental analysis. Extraction conditions (solvent, temperature, duration) were varied to maximize yield of active constituents. Attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) confirmed chemical identity and purity at each processing stage, while gas chromatography-mass spectrometry (GC-MS) identified and quantified volatile components, including the essential oil fraction, yielding a detailed compositional profile. Comparative analysis identified an optimized protocol that improves batch-to-batch consistency, addressing the variability that has long limited the regulatory acceptance of ethnomedicinal coriander-based products. Literature review confirms that coriander seed's bioactive constituents (linalool, terpenes, phenolics, flavonoids) underlie its reported antioxidant, antimicrobial, and anti-inflammatory properties, with efficacy and safety depending strongly on extraction consistency. These results provide a scientific basis for standardizing coriander seed preparation for ethnomedicinal and pharmaceutical use and for formulating evidence-based recommendations for its rational application in Uzbekistan.
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