ASSESSMENT OF RENAL FUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CARDIORENOMETABOLIC SYNDROME
Abstract
The study included 140 patients with AMI admitted to the Cardiac Intensive Care Unit of RSSPMCC, including 90 women and 50 men. Patients were divided into those with (n=58; 41%) and without type 2 diabetes (n=82; 59%). Renal function parameters, including urea, creatinine, uric acid, eGFR, MAU, and albumin-to-creatinine ratio, were assessed according to the 2023 ESC Guidelines. Laboratory analyses were performed using a RANDOX Daytona analyzer, and statistical analysis was conducted with SPSS 27.0. Analysis of laboratory parameters characterizing renal function showed a mean creatinine level of 83.9±27.3 and a mean blood urea level of 6.74±2.59. The mean eGFR among 130 patients in whom it was determined was 76.4±21.1 mL/min/1.73 mІ. According to eGFR, 44 patients (33.8%) had an eGFR ≥90 mL/min/1.73 mІ, 60 patients (46.2%) had an eGFR of 60–89 mL/min/1.73 mІ, 12 patients (9.2%) had an eGFR of 45–59 mL/min/1.73 mІ, 12 patients (9.2%) had an eGFR of 30–44 mL/min/1.73 mІ, and 2 patients (1.5%) had an eGFR <30 mL/min/1.73 mІ. Thus, 26 patients (20.0%) had an eGFR <60 mL/min/1.73 mІ. A significant deterioration in renal function was observed in patients in Group 1. In Group 2, eGFR was 84.0 [65.5; 95.0] mL/min/1.73 mІ, whereas in Group 1 it was 75.0 [56.5; 90.0] mL/min/1.73 mІ (p=0.018). Creatinine levels were significantly higher in Group 1 than in Group 2 (85.0 vs. 75.0; p=0.033). Similarly, blood urea levels were higher in Group 1 (6.95 vs. 5.60; p<0.001).
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