COMORBIDITY AND SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES IN OUTPATIENTS: DATA FROM A REGIONAL REGISTRY OF THE REPUBLIC OF UZBEKISTAN
Abstract
ardiovascular diseases (CVDs) are the leading cause of morbidity and premature mortality in Uzbekistan and Central Asia. The high burden is associated with prevalent modifiable risk factors, particularly hypertension, diabetes, dyslipidemia, obesity, smoking, and physical inactivity. By 2050, CVD mortality in Central Asia is projected to reach 676 deaths per 100,000 population, nearly three times the Asian average, with elevated blood pressure and impaired glucose metabolism being major contributors. In Uzbekistan, CVDs caused approximately 112,000 deaths in 2024, with an age-standardized mortality rate of 523 deaths per 100,000 population. These figures highlight the need to strengthen prevention, early detection, and risk-factor management in primary healthcare, as well as improve outpatient follow-up and evidence-based pharmacotherapy for secondary cardiovascular prevention. To statistically assess comorbidity, major cardiovascular events, and the completeness of evidence-based pharmacological secondary prevention among outpatients using regional registry data. A retrospective population-based study included 372 patients from a regional electronic outpatient registry. Data were summarized using medians and IQRs for quantitative variables and n, %, and 95% CI for categorical variables. Categorical variables were compared using Pearson’s chi-square test, with p<0.05 considered statistically significant.
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