Section 1. XVI Symposium «Current problems of chemistry, biology and technology of natural compounds»

PROTECTIVE EFFECT OF FLATERONE ON MPTP OPENING IN RAT HEART MITOCHONDRIA UNDER OXIDATIVE STRESS

D.Y. Mahmudova 🎤
Faculty of Biology and Ecology, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan
D.X. Muratova
Faculty of Biology and Ecology, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan
G.B. Sotimov
S.Y. Yunusov Institute of the Chemistry of Plant Substances, Uzbekistan
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Abstract

This study aimed to investigate the effect of flaterone on mPTP opening in rat heart mitochondria under oxidative stress conditions in vivo. Flaterone, a flavonoid preparation isolated from Thermopsis alterniflora, was used as the test compound in this study. In the experiment, laboratory rats (220±30 g) were randomly divided into experimental groups (n = 4). All groups except the healthy control group were pretreated with flaterone (100 mg/kg and 50 mg/kg) for 21 days, after which myocardial infarction (MI) was induced using isoproterenol (ISO 85 mg/kg). Serum cardiac troponin I (cTnI) levels were analyzed to confirm MI induction. To assess the change in cardiac mitochondrial membrane permeability under ISO-induced oxidative stress, mitochondrial swelling was monitored at 540 nm.

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Publication Details

Published Date07/10/2026
ConferenceInternational Conference “Biologically active compounds: From chemistry to medicine”
DOI10.5281/zenodo.23061317
Pages193
CC BY 4.0

This article is licensed under a Creative Commons Attribution 4.0 International License.