CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITIES OF Salvia ceratophylla L. FROM EASTERN PART OF TURKIYE
Abstract
In this work, the essential oil composition and antimicrobial activity of Salvia ceratophylla collected from Aрrэ, Eastern Anatolia, were investigated and evaluated for the first time. The essential oil content of aerial parts was evaluated using GC-FID and GC/MS. The antibacterial properties of several extracts obtained from plant, including n-hexane, chloroform, and methanol extracts, respectively and also infusion, were assessed by measuring their minimum inhibitory concentration (MIC) values. As a result, 36 compounds were identified in the oil. The major components were determined as hexahydrofarnesyl acetone (8.8%), camphor (8.4%), caryophyllene (7.8%), caryophyllene oxide (5.7%), germacrene D (5.5%), carvacrol (4.9%), and spathulenol (4.1%). In terms of antimicrobial activity, the extracts had "moderate to weak" inhibitory effects on 6 bacteria and 7 yeasts at concentrations ranging from 125 to 2000 µg/mL for the bacteria and 250 to 2000 µg/mL for the yeasts. Among the extracts, n-hexane and chloroform showed moderate antimicrobial activities while other extracts had weak activity against both microorganisms. In our study, the major compounds of essential oil showed differences comparing the previous studies on S. ceratophylla collected from different parts of Turkiye. Our future research will specifically focus on the pharmacological potential of the extracts and essential oil, along with their phytochemical characterisation.
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