VISIBLE MORTALITY, INVISIBLE DISABILITY: A PILOT DALY-BASED ASSESSMENT OF THE STROKE BURDEN IN UZBEKISTAN
Abstract
For the 2024 population base of 37.1 million, the annual stroke burden fell within the range of 162,512–597,542 DALYs, with a baseline central estimate of 329,439 DALYs — the sum of 248,598 years of life lost (YLL) and 80,841 years lived with disability (YLD). The YLD component constituted 24.5% of the total burden and rose to 30–35% when mild post-stroke disability was taken into account. The working-age population (20–64 years) carried 59.1% of the burden, the 45–64-year group alone accounting for 46.2%; the male-to-female distribution was 55.5/44.5%. About 87% of the modelled burden was attributable to modifiable risk factors, and its economic equivalent approached 0.82% of annual gross domestic product. A DALY-based TOP-10 ranking of causes differed markedly from the conventional mortality ranking: depression, low back pain, neonatal disorders and migraine entered the list, whereas chronic obstructive pulmonary disease and liver cirrhosis moved downwards. The ratio between registered stroke deaths and total stroke DALYs reached approximately twentyfold, illustrating a pronounced “iceberg effect”.
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