SYNTHESIS OF UREA-BRIDGED ARYL-HETERYL HYBRID MOLECULES
Abstract
Quinazolin-4(3H)-one derivatives are an important class of nitrogen-containing heterocyclic compounds with diverse biological activities, including anticancer, antimicrobial, anti-inflammatory and antiviral properties. In addition, the urea pharmacophore is present in several clinically approved anticancer drugs, such as Sorafenib and Lenvatinib. Therefore, the combination of quinazolinone and urea fragments into a single molecular framework represents a promising molecular hybridization strategy for the development of novel biologically active compounds [1,2]. Based on this concept, the present study was aimed at the synthesis of a series of urea-bridged aryl-heteryl hybrid molecules using 2-amino-3-methylquinazolin-4(3H)-one as the key intermediate. The strategy involved the functionalization of 2-amino-3-methylquinazolin-4(3H)-one through reactions with substituted phenyl isocyanates, leading to the formation of structurally diverse urea derivatives. The proposed methodology afforded the target compounds in satisfactory yields and may provide a useful platform for the development of biologically active quinazolinone derivatives.
References
- Hans J. Hess, Timothy H. Cronin, Alexander Scriabine. (1968). Antihypertensive 2-amino-4(3H)-quinazolinones.Journal of Medicinal Chemistry.[Crossref]
- Sara P. S. P. Moura, Silvia Marín, Ismael Rufino, Rita C. Guedes, Marta Cascante, Jorge A. R. Salvador. (2024). Design, Synthesis, and Biological Evaluation of Novel Urea-Containing Carnosic Acid Derivatives with Anticancer Activity.International Journal of Molecular Sciences.[Crossref]
Publication Details
This article is licensed under a Creative Commons Attribution 4.0 International License.