SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF UNSYMMETRICAL ARYL-HETERYL UREA HYBRIDS

Abstract

In the present study, o-tolylisocyanate was reacted with 2-amino-4-methyl-3,5-diethoxycarbonylthiophene (2), ethyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate (3), and ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4). As a result of these reactions aryl-heteryl urea hybrids (5-7) were isolated in 60-68% yields. The structures of the synthesized compounds were confirmed by IR, 1H NMR spectroscopy and mass spectrometry.

References

1. Arun K. Ghosh, Margherita Brindisi. (2019). Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry.Journal of Medicinal Chemistry.[Crossref]
2. Riccardo Ronchetti, Giada Moroni, Andrea Carotti, Antimo Gioiello, Emidio Camaioni. (2021). Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.RSC Medicinal Chemistry.[Crossref]
3. Roberta Listro, Giacomo Rossino, Federica Piaggi, Falilat Folasade Sonekan, Daniela Rossi, Pasquale Linciano, Simona Collina. (2022). Urea-based anticancer agents. Exploring 100-years of research with an eye to the future.Frontiers in Chemistry.[Crossref]
4. Shikha Kaushik, Neeraj Masand, Malliga R. Iyer, Vaishali M. Patil. (2023). Preclinical to Clinical Profile of Curcuma longa as Antidiabetic Therapeutics.Current Topics in Medicinal Chemistry.[Crossref]

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