ENZYMATIC SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 3'-DEOXYRIBONUCLEOSIDE ANALOGUES OF RIBAVIRIN
Abstract
3'-Deoxyribonucleosides are an important class of modified nucleosides. The key structural feature of which is the absence of a hydroxyl group in the third position of the ribose fragment. This modification causes increased resistance of compounds to the action of cellular enzymes, and also gives them new biological properties that differ from their natural counterparts. The most effective approach to obtaining such structures is enzymatic transglycosylation catalyzed by purine nucleoside phosphorylase (PNP) and uridine phosphorylase (UP). These studies are particularly relevant in the context of the search for safe substitutes for ribavirin, a well-known antiviral drug whose use is associated with toxicity and side effects. In solving this problem, our attention was focused on the synthesis of 3'-deoxyribonucleosides containing 1,2,4-triazole-3-carboxamide fragments modified by amino groups with various substituents.
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