CURCUMIN/CHALCONE-DERIVED SCAFFOLDS AS PROMISING BIOACTIVE AGENTS: A JOURNEY FROM SYNTHESIS TO BIOLOGICAL EVALUATION
Abstract
This study highlights the relationship between curcumin and chalcone chemistry, addressing synthetic strategies used to convert curcumin-inspired structures into biologically active chalcone derivatives. Emphasis is placed on recent advances in the synthesis, structural diversification, and biological evaluation of these compounds. Reported studies demonstrate that curcumin/chalcone derivative scaffolds exhibit significant anticancer, antibacterial, antifungal, antioxidant, and anti-inflammatory activities through various molecular mechanisms, including apoptosis induction, enzyme inhibition, modulation of reactive oxygen species, and interference with cellular signaling pathways. Overall, curcumin-inspired chalcone derivatives continue to represent a promising class of multifunctional bioactive agents. The integration of rational design, synthetic modification, and biological evaluation offers valuable opportunities for the discovery of novel therapeutic candidates with improved efficacy and pharmacological performance.
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