ACUTE TOXICITY AND ANTIARRHYTHMIC ACTIVITY OF THE ALKALOID NITRARIDINE
Abstract
Relevance of the study. Cardiac arrhythmias are frequently encountered in clinical practice and pose a threat to the patient's life. It is well known that cardiovascular disease ranks first among causes of death in various countries. One of the frequently occurring symptoms that worsens the course and outcome of cardiovascular diseases is arrhythmia. herefore, the clinical need for effective antiarrhythmic drugs of various spectrums and mechanisms of action is very high. In our experiments, novocainamide restored impaired cardiac activity in 2 (33.3%) cases out of 6, reduced the number of ectopic heart contractions in 2 (33.3%) experiments, and had no therapeutic effect on aconitine arrhythmia in the remaining cases. Prophylactic administration of novocainamide at the dose indicated above did not prevent the development of aconitine-induced cardiac arrhythmia in any case out of 6 experiments, although in 4 (66.6%) experiments, arrhythmia under the influence of novocainamide developed somewhat later (by 8-12 minutes) than in the control. When studying the effect of nitraridine on the bioelectrical activity of the heart in rats, it was found that nitraridine at doses of 3-5 mg/kg did not significantly affect the ECG parameters of the rats' hearts, and at a dose of 10 mg/kg it mainly lengthened the R-R interval by 10-14.2%. Thus, nitraridine is of practical interest as a less toxic antiarrhythmic drug.
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