COMBINATION OF PHOTOCATALYSIS AND CONTINUOUS-FLOW TECHNOLOGY FOR THE SYNTHESIS OF BIOACTIVE COMPOUNDS AND ITS PRECURSORS

Abstract

The combination of photoredox catalysis and continuous-flow technology provides a powerful approach to the synthesis of valuable organic compounds that are difficult to access using traditional stoichiometric or metal-catalyzed methods. The precise control of reaction parameters, efficient irradiation, and enhanced mass and heat transfer offered by continuous-flow systems can improve the efficiency, reproducibility, and scalability of photochemical transformations. We have developed several efficient continuous-flow approaches to photochemical transformations, enabling the synthesis of bioactive compounds, their precursors, and derivatives. These include trifluoromethylation of (het)arenes [1], N-(hetero)arylation of amines [2], C(sp3)-heteroarylation [3], trifluoromethoxylation [4] and photocatalytic E→Z isomerization of alkenes. In these transformations, continuous-flow technology enabled efficient light utilization and precise control over reaction conditions, providing a practical platform for the development and intensification of photochemical synthetic processes. Overall, our results demonstrate the potential of combining photoredox catalysis with continuous-flow technology for the efficient synthesis of structurally diverse and potentially bioactive organic compounds, while offering opportunities for improved scalability and process efficiency.

References

1. Egor N Boronin, Svetlana E Kaurkina, Milena M Svetlakova, Anton S Bolshakov, Maxim V Arsenyev, Vasilii F Otvagin, Alexey Yu Fedorov, Timothy Noël, Alexander V Nyuchev. (2026). Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions.Beilstein Journal of Organic Chemistry.[Crossref]
2. A.V. Nyuchev et al. Reaction Chemistry & Engineering 2024, 9, 7, 1877–1882.
3. Ting Wan, Luca Capaldo, Gabriele Laudadio, Alexander V. Nyuchev, Juan A. Rincón, Pablo García‐Losada, Carlos Mateos, Michael O. Frederick, Manuel Nuño, Timothy Noël. (2021). Decatungstate‐Mediated C(sp³)–H Heteroarylation via Radical‐Polar Crossover in Batch and Flow.Angewandte Chemie International Edition.[Crossref]
4. Alexander V Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J C Struijs, Michelle Ho, Moisés Gulías, Ying Wang, Timothy Noël. (2020). Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow.Beilstein Journal of Organic Chemistry.[Crossref]

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