TERPENOIDS FROM FERULA AND PHYLLANTHUS SPP. AND THEIR BIOLOGICAL ACTIVITIES
Abstract
Terpenoids are a class of widely distributed natural products with a wide range of biological activities. Based on the number of isoprene units and the structure of their carbon rings, they are classified generally into mono-, sesqui- (SQT), di- (DT), sester-, tri- (TT), and tetra- terpenoids. Ferula lapidosa, a Apiaceous perennial herb, is endemic to Central Asia and has been used medicinally by people of its growing area. Phyllanthus emblica and P. acidus, are edible fruit trees in family Phyllanthaceae, have also been used widely as ethnomedicines. Their chemical constituents were studied, leading to the isolation of 83 compounds including 1 new iridoid glycoside, 20 new SQT lactones, and 4 new SQT esters from F. lapidosa, 181 molecules including 32 new SQT and 6 new DT from P. emblica, and 103 compounds with 22 new SQT, 13 new DT, and 32 new dichapetalin TT (DTTs) from P. acidus (Fig. 1). Their structures were determined by extensive spectroscopic analyses, ECD calculation and single-crystal X-ray diffraction. It is noted, the SQT displayed anti CVB3, HBV, H3N2, EV71 activities, while DT and DTTs showed obvious cytotoxicities on several human cancer cell lines
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