RECENT PHYTOCHEMICAL STUDIES ON Astragalus, Polygala, AND Teucrium SPECIES

Abstract

Our continuing investigations of plants from the flora of Türkiye and other parts of the Mediterranean Basin have resulted in the isolation and structural characterization of numerous classes of secondary metabolites. Our recent studies have focused on Astragalus L. species belonging to the family Fabaceae, Teucrium L. species from the Lamiaceae, and Polygala L. species from the Polygalaceae. The plants investigated were collected in Türkiye and Libya. These studies led to the isolation of structurally diverse natural products, including oleanane- and cycloartane-type triterpene saponins from Astragalus species [1]. The results of our ongoing phytochemical investigation of the roots of Astragalus ihsancalisii Dönmez & Uğurlu will be presented in detail [2]. Teucrium davaeanum Coss. and T. zanonii Pamp. are medicinal plants traditionally used in Libya for their antidiabetic properties. Phytochemical investigations of the aerial parts of these plants resulted in the isolation of diglycosidic iridoids, phenylethanoid triglycosides, di-C-glycosyl flavonoids, and oleanane-type bisdesmosidic saponins [3]. Studies on selected Polygala species from the flora of Türkiye afforded lignans, xanthones, sucrose and oligosaccharide multiesters, and oleanane-type ester saponins [4,5]. The structures of the isolated compounds were elucidated through chemical derivatization and spectroscopic methods, including UV and IR spectroscopy, one- and two-dimensional NMR spectroscopy, and high-resolution mass spectrometry. This presentation will provide an overview of these recent findings, with particular emphasis on the resolution of challenging structural problems through the complementary use of chemical and spectroscopic techniques.

References

1. Güner Ekiz Dinçman, Zeki Aytaç, İhsan Çalış. (2024). Turkish Astragalus Species: Botanical Aspects, Secondary Metabolites, and Biotransformation.Planta Medica.[Crossref]
2. İhsan Çalış, Azmi Hanoğlu, Zübeyde Uğurlu Aydın, Ali A. Dönmez, Simon Jurt. (2025). Phytochemical studies on the roots of <i>Polygala vulgaris</i>.Natural Product Research.[Crossref]
3. Randa Aldaba, Azmi Hanoğlu, Duygu Yiğit Hanoğlu, Kemal Hüsnü Can Başer, Mehmet Öztürk, Ahmet Ceyhan Gören, Simon Jurt, İhsan Çalış. (2026). Comparative Phytochemical Studies on the Aerial Parts of Teucrium davaeanum Coss. and Teucrium zanonii Pamp..Molecules.[Crossref]
4. Ayşe Ünlü, Kerem Teralı, Zübeyde Uğurlu Aydın, Ali A. Dönmez, Hasan Soliman Yusufoğlu, İhsan Çalış. (2022). Isolation, Characterization and In Silico Studies of Secondary Metabolites from the Whole Plant of Polygala inexpectata Peşmen &amp; Erik.Molecules.[Crossref]
5. İhsan Çalış, Ayşe Ünlü, Zübeyde Uğurlu Aydın, Ali A. Dönmez, Hasan Soliman Yusufoğlu, Simon Jurt, Anthony Linden. (2022). Xanthones and Xanthone <i>O</i>‐<i>β</i>‐D‐Glucosides from the Roots of <i>Polygala azizsancarii</i> Dönmez.Chemistry &amp; Biodiversity.[Crossref]

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