DESIGN AND SYNTHESIS OF NEW HETEROCYCLIC COMPOUNDS

Abstract

Compounds classified as heterocyclic probably constitute the largest and most varied family of organic compounds and they are well presented among pharmaceuticals. As part of our ongoing research program on the design and synthesis of heterocycles with new skeletons we developed new methodologies. The key feature of this methodology was the synthesis of N-propargyl pyrrole, indole, and benzene derivatives. The gold-catalyzed reaction of pyrrole and indole oximes having N-propargyl group transferred the oxime functionality intramolecularly from one carbon atom to another carbon atom via 7-endo-dig cyclization process.

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