PHYTOCHEMICAL INVESTIGATION AND COMMERCIALIZATION OF HEALTH-IMPROVING PRODUCTS FROM MEDICINAL AND EDIBLE PLANT RESOURCES OF KAZAKHSTAN
Abstract
Kazakhstan, located in the heart of Central Asia, boasts rich medicinal plant resources. Medicinal and edible plants continue to receive significant research attention due to their proven pharmacological effects, including antioxidant, antidiabetic, antitumor, anti-inflammatory, and antibacterial properties. These therapeutic benefits are attributed to the diverse bioactive secondary metabolites present in the plants, such as flavonoids, triterpenoids, steroids, alkaloids, saponins, proteins, and amino acids. Our aim to search promising, potential active Artemisia species candidates, encouraging us to analyze Protein Tyrosine Phosphatase 1B (PTP1B), α-glucosidase, bacterial neuraminidase (BNA) inhibition and antioxidant potentials of nine Artemisia plant extracts in which mostly endemic species have not been explored their secondary metabolites and bioactivities so far. Among all species A. scopaeformis, A. albicerata, A. transiliensis, A. nitrosa, and A. albida showed has a high potential to α-glucosidase, PTP1B and BNA inhibition. We focused on Artemisia albida Willd., a semi-white wormwood native to several regions of Kazakhstan, including Almaty, Altai, Tarbagatai, Zaysan, and Akmola. From the dichloromethane extract of A. albida, we isolated 30 compounds. Their structures were elucidated using HRMS, NMR, and other spectroscopic methods, revealing two previously undescribed sesquiterpenoids.
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